Beginning:
Everyone knows that an exciting beginning is important, both to potential publishers and readers. However, you shouldn't stress too much about having the kind of first sentence that will go down in history. Just focus on setting the tone of the book for now.
You're going to want to start in the middle of some sort of problem. Don't have your characters wait around for something to happen. Give them things to deal with and show their personalities through that.
Show the character under some kind of stress. Your main character is hopefully going to grow and change during his or her adventure. So, if your character suffers from OCD, show them doing some sort of compulsive action that they will finally be able to stop doing by the end of the novel. Do some sort of foreshadowing.
It's important when you start writing not to edit yourself. Just let the ideas and words flow. You'll get to look at it more closely later.
Middle:
Well, this is where things really happen. And follow that annoying guideline of “show, don't tell.” It really is important.
Your character should also be an active problem solver. Nothing should seem random or unrealistically lucky. Good things should happen because your character makes them happen.
Your character's motivation is also really important. You don't want your readers thinking, “Would she really do that?”
End:
Well, here it is! Your character solves the problem (or doesn't.) The stakes should be high so that it all rides on what your character does. Tie up any loose ends and pat yourself on the back. Your work here is done...for now. Reread in a couple of weeks and start the fun, thrilling editing process.